רבי יצחק בן יעקב קנפנטון היה מגדולי חכמי ספרד בדור שלפני הגירוש, היה ראש ישיבה, מקובל, רופא, מתמטיקאי, ואיש ציבור.
Isaac ben Jacob Canpanton (1360–1463) was a Spanish rabbi. He lived in the period darkened by the outrages of Ferrand Martinez and Vicente Ferrer, when intellectual life and Talmudic erudition were on the decline among the Jews of Spain. The historiographers Immanuel Aboab, Zacuto, and Joseph ben Zaddik unite in designating Canpanton as a gaon, Aboab stating that he was styled "the gaon of Castile". Among his pupils may be mentioned Samuel al-Valensi, Isaac Aboab, and Isaac De Leon. He died at Peñafiel in 1463.